Increased cortical inhibition induced by apomorphine in patients with Parkinson's disease
Identifieur interne : 001E83 ( Main/Exploration ); précédent : 001E82; suivant : 001E84Increased cortical inhibition induced by apomorphine in patients with Parkinson's disease
Auteurs : L. Manfredi [Italie] ; P. Garavaglia [Italie] ; S. Beretta [Italie] ; G. Pellegrini [Italie]Source :
- Neurophysiologie Clinique / Clinical Neurophysiology [ 0987-7053 ] ; 1997.
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Abstract
The electromyographic silent period following the motor potential evoked hy cortical magnetic stimulation is decreased in parkinsonian patients. In this study we investigated whether the decrease in the silent period is connected only with parkinsonian symptoms. We evaluated the effect of apomorphine (a potent and rapid dopamine agonist) on the changes in the peripheral and central silent period in 29 patients with Parkinson's disease and in two patients affected by multisystem atrophy (MSA). Apomorphine injection was found to induce a significant improvement in the central silent period in parkinsonian patients but not in the MSA patients, suggesting a relation between the clinical parkinsonian symptoms (akinesia and rigidity) and the silent period duration. The central silent period changes after apomorphine injection could be used as an adjunctive, safe and effective diagnostic tool to assess dopamine responsiveness of parkinsonian syndromes.
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DOI: 10.1016/S0987-7053(97)89576-7
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Manfredi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Ospedale Valduce, via Dante 11, 22100 Como</wicri:regionArea><wicri:noRegion>22100 Como</wicri:noRegion></affiliation></author><author><name sortKey="Garavaglia, P" sort="Garavaglia, P" uniqKey="Garavaglia P" first="P" last="Garavaglia">P. Garavaglia</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Ospedale Valduce, via Dante 11, 22100 Como</wicri:regionArea><wicri:noRegion>22100 Como</wicri:noRegion></affiliation></author><author><name sortKey="Beretta, S" sort="Beretta, S" uniqKey="Beretta S" first="S" last="Beretta">S. 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Pellegrini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Ospedale Valduce, via Dante 11, 22100 Como</wicri:regionArea><wicri:noRegion>22100 Como</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurophysiologie Clinique / Clinical Neurophysiology</title><title level="j" type="abbrev">NEUCLI</title><idno type="ISSN">0987-7053</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="31">31</biblScope><biblScope unit="page" to="38">38</biblScope></imprint><idno type="ISSN">0987-7053</idno></series><idno type="istex">A73822474395398FCC945642CE266E73634B234F</idno><idno type="DOI">10.1016/S0987-7053(97)89576-7</idno><idno type="PII">S0987-7053(97)89576-7</idno><idno type="ArticleID">97895767</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0987-7053</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cortical stimulation</term><term>multiple system atrophy</term><term>silent period</term><term>transcranial stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The electromyographic silent period following the motor potential evoked hy cortical magnetic stimulation is decreased in parkinsonian patients. In this study we investigated whether the decrease in the silent period is connected only with parkinsonian symptoms. We evaluated the effect of apomorphine (a potent and rapid dopamine agonist) on the changes in the peripheral and central silent period in 29 patients with Parkinson's disease and in two patients affected by multisystem atrophy (MSA). Apomorphine injection was found to induce a significant improvement in the central silent period in parkinsonian patients but not in the MSA patients, suggesting a relation between the clinical parkinsonian symptoms (akinesia and rigidity) and the silent period duration. The central silent period changes after apomorphine injection could be used as an adjunctive, safe and effective diagnostic tool to assess dopamine responsiveness of parkinsonian syndromes.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Manfredi, L" sort="Manfredi, L" uniqKey="Manfredi L" first="L" last="Manfredi">L. Manfredi</name></noRegion><name sortKey="Beretta, S" sort="Beretta, S" uniqKey="Beretta S" first="S" last="Beretta">S. Beretta</name><name sortKey="Garavaglia, P" sort="Garavaglia, P" uniqKey="Garavaglia P" first="P" last="Garavaglia">P. Garavaglia</name><name sortKey="Pellegrini, G" sort="Pellegrini, G" uniqKey="Pellegrini G" first="G" last="Pellegrini">G. Pellegrini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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